Bone Abstracts

Kit ligand/c-Kit receptor tyrosine kinase complex has been implicated as a target for bone remodeling process. Loss of function mutation in c-Kit causes low bone mass in KitW/W-v (W/Wv) mice. However, these mice are sterile and it is unclear whether the observed skeletal phenotype is secondary to sex hormone deficiency. To address this question, the skeletal phenotype of KitW...

Breastfeeding leads to marked trabecular bone loss as a result of high osteoclast- and osteocyte-mediated bone resorption. It has long been postulated that adequate dietary calcium intake prevents maternal bone loss, nevertheless, whether calcium supplement alleviates maternal bone mechanical property need to be investigated. Herein, we hypothesized that calcium supplement from natural sources could alleviate bone loss and improve mechanical property in lactating rats. During ...